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阿培利司 Alpelisib

簡要描述:阿培利司 Alpelisib
Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

  • 產品型號:型號齊全
  • 廠商性質:代理商
  • 更新時間:2023-07-12
  • 訪  問  量:545
詳情介紹

Product Name: 阿培利司 Alpelisib

Description: Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Alpelisib is equipotent against both wild type and several mutant isoforms (IC50s = 4.0-4.8 nM). eCollection 2020. Navitoclax combined with Alpelisib effectively inhibits Merkel cell carcinoma cell growth in vitro. Alpelisib Plus Letrozole Shows Promise After CDK 4/6 Inhibitor Therapy in PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.

Name: Alpelisib
CAS#: 1217486-61-7
Chemical Formula: C19H22F3N5O2S
Exact Mass: 441.14463
Molecular Weight: 441.47
Elemental Analysis: C, 51.69; H, 5.02; F, 12.91; N, 15.86; O, 7.25; S, 7.26

Synonym: NVP-BYL719; NVP-BYL-719; NVP-BYL 719; BYL719; BYL-719; BYL 719; Alpelisib

IUPAC/Chemical Name: (S)-N1-(4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide.

InChi Key: STUWGJZDJHPWGZ-LBPRGKRZSA-N

InChi Code: InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1

SMILES Code: O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CC(C(C)(C)C(F)(F)F)=NC=C3)S2

Appearance: white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001




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