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尼拉帕尼 Niraparib

簡要描述:尼拉帕尼 Niraparib
Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells.

  • 產品型號:型號齊全
  • 廠商性質:代理商
  • 更新時間:2023-07-12
  • 訪  問  量:528
詳情介紹

Product Name: 尼拉帕尼 Niraparib

Description: Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.

Name: Niraparib free base
CAS#: 1038915-60-4 (free base)
Chemical Formula: C19H20N4O
Exact Mass: 320.1637
Molecular Weight: 320.4
Elemental Analysis: C, 71.23; H, 6.29; N, 17.49; O, 4.99

Synonym: MK-4827; MK 4827; MK4827; Niraparib. Niraparib free base; Zejula.

IUPAC/Chemical Name: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

InChi Key: PCHKPVIQAHNQLW-CQSZACIVSA-N

InChi Code: InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1

SMILES Code: O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N

Appearance: Light yellow solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001





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