Aromadendrene

Description: Aromadendrene is a sesquiterpene that has been found in E. globulus and has diverse biological activities. It is active against various strains of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci (VRE; MICs = 0.25-1 mg/ml). Aromadendrene (1 mM) inhibits tert-butyl hydroperoxide-induced formation of thiobarbituric acid reactive substances (TBARS) in isolated rat liver hepatocytes. It inhibits the proliferation of HepG2 liver and PC3 prostate cancer cells (IC50s = 20 and 9.3 µM, respectively).

Synonym: l-Aromadendrene; Aromadendrene, (-)-; beta-Diploalbicene; (-)-10(14)-Aromadendrene; (+)-Aromadendrene;

IUPAC/Chemical Name: (1aS,4aS,7S,7aS,7bR)-1,1,7-trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulene

InChi Key: ITYNGVSTWVVPIC-NDKCEZKHSA-N

InChi Code: InChI=1S/C15H24/c1-9-6-8-12-14(15(12,3)4)13-10(2)5-7-11(9)13/h10-14H,1,5-8H2,2-4H3/t10-,11+,12-,13-,14-/m0/s1

SMILES Code: C=C1CC[C@@]2([H])[C@@](C2(C)C)([H])[C@@]3([H])[C@@H](C)CC[C@]13[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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