IUPAC/Chemical Name: (2R,3R,4S,5R)-2-(2,6-dichloro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 2,6-Dichloropurine riboside

Synonym: 2,5-dimethyl Celecoxib, DMC IUPAC/Chemical Name: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

Synonym: 25-Desacetylrifapentine; L-14583; L 14583; L14583;

AY77 is a Potent protease activated receptor 2 (PAR2) calcium-biased agonist (EC50 40 nM, Ca2+; EC50 2 µM, ERK1/2).

AY 254 is a potent PAR2 biased agonist. It selectively activates ERK1/2 signaling (EC50 = 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+ release).